FoundationOne® Heme

O Foundation-One HEME é um ensaio baseado em sequenciamento de nova geração (NGS) que identifica alterações genômicas em centenas de genes relacionados ao câncer.ABL1, ACTB, AKT1, AKT2, AKT3, ALK, AMER1 (FAM123B ou WTX), APC, APH1A, AR, ARAF, ARFRP1, ARHGAP26(GRAF), ARID1A, ARID2, ASMTL, ASXL1, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXL, B2M, BAP1, BARD1, BCL10, BCL11B, BCL2, BCL2L2, BCL6, BCL7A, BCOR, BCORL1, BIRC3, BLM, BRAF, BRCA1, BRCA2, BRD4, BRIP1 (BACH1), BRSK1, BTG2, BTK, BTLA, C11orf3O (EMSY), CAD, CALR, CARD11, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CCT6B, CD22, CD274 (PD-L1), CD36, CD58, CD70, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK 8, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHD2, CHEK1, CHEK2, CIC, CIITA, CKS1B, CPS1, CREBBP, CRKL, CRLF2, CSF1R, CSF3R, CTCF, CTNNA1, CTNNB1, CUX1, CXCR4, DAXX, DDR2, DDX3X, DNM2, DNMT3A, DOTIL, DTX1, DUSP2, DUSP9, EBF1, ECT2L, EED, EGFR, ELP2, EP300, EPHA3, EPHA5, EPHA7, EPHB1 ERBB2, ERBB3, ERBB4, ERG, ESR1, ETS1, ETV6, EXOSC6, EZH2, FAF1, FAM46C, FANCA, FANCC, FANCD2, FANCE, FANCF, FANCG, FANCL, FAS (TNFRSF6), FBXO11, FBXO31, FBXW7, FGF10, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FHIT, FLCN, FLT1, FLT3, FLT4, FLYWCH1, FOXL2, FOXO1, FOXO3, FOXP1, FRS2, GADD45B, GATA1, GATA2, GATA3, GID4 (C17orf39), GNA11, GNA12, GNA13, GNAQ, GNAS, GPR124, GRIN2A, GSK3B, GTSE1, HDAC1, HDAC4, HDAC7, HGF, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H2AC, HIST1H2AG, HIST1H2AL, HIST1H2AM, HIST1H2BC, HIST1H2BJ, HIST1H2BK, HIST1H2BO, HIST1H3B, HNF1A, HRAS, HSP90AA1, ICK, ID3, IDH1, IDH2, IGF1R, IKBKE, IKZF1, IKZF2, IKZF3, IL7R, INHBA, INPP4B, INPP5D (SHIP), IRF1, IRF4, IRF8, IRS2, JAK1, JAK2, JAK3, JARID2, JUN, KAT6A (MYST3), KDM2B, KDM4C, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KIT, KLHL6, KMT2A (MLL), KMT2C (MLL3), KMT2D (MLL2), RAS, LEF1, LRP1B, LRRK2, MAF, MAFB, MAGED1, MALT1, MAP2K1 (MEK1), MAP2K2 (MEK2), MAP2K4, MAP3K1, MAP3K14, MAP3K6, MAP3K7, MAPK1, MCL1, MDM2, MDM4, MED12, MEF2B, MEF2C, MEN1, MET, MIB1, MITF, MKI67, MLH1, MPL, MRE11A, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCL (MYCL1), MYCN, MYD88, MYO18A, NCOR2, NCSTN, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NOD1, NOTCH1, NOTCH2, NPM1, NRAS, NT5C2, NTRK1, NTRK2, NTRK3, NUP93, NUP98, P2RY8, PAG1, PAK3, PALB2, PASK, PAX5, PBRM1, PC, PCBP1, PCLO, PD GDI (PD-1), PDCD11, PDCD1LG2 (PD-L2), PD GFRA, PDGFRB, PDK1, PHF6, PIK3CA, PIK3CG, PIK3R1, P/IK3R2, PIM1, PLCG2, POT1, PPP2R1A, PRDM1, PRKAR1A, PRKDC, PRSS8, PTCH1, PTEN, PTPN11, PTPN2, PTPN6 (SHP-1), PTPRO, RAD21, RAD50, RAD51, RAF1, RARA, RASGEF1A, RBI, RELN, RET, RHOA, RICTOR, RNF43, ROS7, RPTOR, RUNX7, S1PR2, SDHA, SDHB, SDHC, SDHD, SERP2, SETBP1, SETD2, SF3B1, SGK1, SMAD2, SMAD4, SMARCA1, SMARCA4, SMARCB1, SMC1A, SMC3, SMO, SOCS1, SOCS2, SOCS3, SOX10, SOX2, SPEN, SPOP, SRC, SRSF2, STAG2, STAT3, STAT4, STAT5A, STAT5B, STAT6, STK11, SUFU, SUZ72, TAF1, TBL1XR1, TCP3 (E2A), TCL1A (TCU), TET2, TGFBR2, TLL2, TMEM30A, TMSB4XP8 (TMSL3), TNFAIP3, TNFRSF11A, TNFRSF14, TNFRSF17, TOPI, TP53, TP63, TRAF2, TRAF3, TRAF5, TSC1, TSC2, TSHR, TUSC3, TTKZ, U2AF1, U2AF2, VHL, WDR90, WHSC1 (MMSET ou NSD2), WISP3, WT1, XBP1, XPO1, YY1AP1, ZMYMJ, ZNF217, ZNF24 (ZSCAN3), ZNF703, ZRSR2Rearranjos Selecionados do DNA3:ALK, BCL2, BCL6, BCR, BRAF, CCND1, CRLF2, EGFR, EPOR, ETV1, ETV4, ETV5, ETV6, EWSR1, FGFR2, IGH, G/C, IGL, JAK1, JAK2, KMT2A (MLL), MYC, NTRK1, PDGFRA, PDGFRB, RAF1, RARA, RET, ROS1, TMPRSS2, TRGFusões de genes de RNA Selecionados:ABl1, ABL1, ABL2, ACSL6, AFF1, AFF4, ALK, ARHGAP26 (GRAF), ARHGEF12, ARID1A, ARNT, ASX1L1, ATF1, ATG5 ATIC, BCL10 BCL11A, BCL11B, BCL2, BCL3, BCL6, BCL7A, BCL9, BCOR, BCR, BIRC3, BRAF, BTG1, CAMTA1, CARS, CBFA2T3, CBFB, CBL, CCND1, CCND2, CCND3, CD274 (PD-U), CDK6, CDX2, CHIC2, CHN1, CIC, CIITA, CLP1, CLTC, CLTCLI, CNTRL (CEP110), COL1A1, CREB3L1, CREB3L2, CREBBP, CRLF2, CSF1, CTNNB1, DDIT3, DDX10, DDX6, DEK, DUSP22, EGFR, EIF4A2, ELF4, ELL, ELN, EML4, EP300, EPOR, EPS15, ERBB2, ERG, ETS1, ETV1, ETV4, ETV5, ETV6, EWSR1, FCGR2B, FCRL4, FEV, FGFR1, FGFRIOP, FGFR2, FGFR3, FLI1, FNBP1, FOXO1, FOXO3, FOXO4, FOXP1, FSTL3, FUS, GAS7, GLI1, GMPS, GPHN, HERPUD1, HEY1, HIP1, HIST1H4I, HLF, HMGA1, HMGA2, HOXA11, HOXA13, HOXA3, HOXA9, HOXC11, HOXC73, HOXD11, HOXD13, HSP90AA1, HSP90ABI, IGH, IGK, IGL, IKZF1, IL21R, IL3, IRF4, ITK, JAX7, JAK2, JAK3, JAZF1, KAT6A (MYST3), KDSR, KIF5B, KMT2A (MLL), LASP1, LCP1, LMOI, LMO2, LPP, LYL1, MAF, MAFB, MALT1, MDS2, MECOM, MKL1, MLF1, MLLT1 (END), MLLT10 (AF10), MLLT3, MLLT4 (AF6), MLLT6, MN1, MNX1, MSI2, MSN, MUC1, MYB, MYC, MYH11, MYH9, NACA, NBEAP1 (BCL8), NCOA2, NDRG1, NF1, NF2, NFKB2, NIN, NOTCH1, NPM1, NR4A3, NSD1, NTRK1, NTRK2, NTRK3, NUMA1, NUP214, NUP98, NUTM2A, OMD, P2RYB, PAFAH1B2, PAX3, PAX5, AAX7, PBX1, PCM1, PCSX7, PDCD1LG2 (PD-L2), PDE4DIP, PDGFB, PDGFRA, PDGFRB, PER1, PHF1, PICALM, PIM1, PLAG1, LMP, POU2AF1, PPP1CB, PRDM1, PRDM16, PRRXJ, PSIP1, PTCH1, PTK7, RABEP1, RAF1, RALGDS, RAP1GDS1, RARA, RBM15, RET, RHOH, RNF213, ROS1, RPL22, RPN1, RUNX1, RUNX1T1 (ETO), PLWXZ, SEC31A, SEPT5, SEPT6, SEPT9, SET, SH3GL1, SLC7A2, SNX29 (RUNDC2A), SRSF3, SS18, SSX1, SSX2, SSX4, STAT6, STL, SMC, TAF15, TALI, TAL2, TBL1XR1, TCF3 (E2A), TCL1A (TCL1), TEC, TET1, TFE3, TFG, TFPT, TFRC, TLX1, TLX3, TMPRSS2, TNFRSF11A, TOPI, TP63, TPM3, TPM4, TRIM24, TRIPP, TTL, TYK2, USP6, WHSC1 (MMSET ou NSD2), WHSC1L1, YPEL5, ZBTB16, ZMXMZ, ZNF384, ZNF521